Protein Details: Aquaporin-0

Protein ID

ICDB_Pro_0459

Protein Name

Aquaporin-0

Gene Name

MIP

Organism

Gallus gallus (Chicken)

Length

262 amino acids

AlphaFoldDB

AF-P28238-F1-model_v4.pdb

Function

Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Sequence

MRELRSSSFWRAILAEFLGSLLYTLLGLGASLRWAPGPHGVLGSALAFGLAQATLVQALGHVSGGHINPAITLAFLLASQLSLPRALGYLLAQLLGALAGAGVLYGVTPAAVRGTLGLSALHPSVGPGQGTVVELLLTAQFILCVFASFDDRHDGRPGSAALPVGFSLALGHLFGIPFTGAGMNPARSFAPAVITRNFTNHWVFWAGPLLGAALAALLYELALCPRARSMAERLAVLRGEPPAAAPPPEPPAEPLELKTQGL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Major component of lens fiber gap junctions

DOI ID

10.1242/jcs.00945; 10.1016/0014-4835(90)90123-c

RefSeq

NP_989597.1